Lanlan Zhou Selected Research

TIC10 compound

1/2023	Novel combination of imipridones and histone deacetylase inhibitors demonstrate cytotoxic effect through integrated stress response in pediatric solid tumors.
1/2023	ONC201/TIC10 plus TLY012 anti-cancer effects via apoptosis inhibitor downregulation, stimulation of integrated stress response and death receptor DR5 in gastric adenocarcinoma.
1/2023	Synergistic activity of ABT-263 and ONC201/TIC10 against solid tumor cell lines is associated with suppression of anti-apoptotic Mcl-1, BAG3, pAkt, and upregulation of pro-apoptotic Noxa and Bax cleavage during apoptosis.
1/2022	Preclinical studies with ONC201/TIC10 and lurbinectedin as a novel combination therapy in small cell lung cancer (SCLC).
12/2021	Combination of ONC201 and TLY012 induces selective, synergistic apoptosis in vitro and significantly delays PDAC xenograft growth in vivo.
12/2021	Antitumorigenic effect of combination treatment with ONC201 and TRAIL in endometrial cancer in vitro and in vivo.
1/2021	Absence of Biomarker-Driven Treatment Options in Small Cell Lung Cancer, and Selected Preclinical Candidates for Next Generation Combination Therapies.
1/2021	EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG.
1/2021	Potent preclinical sensitivity to imipridone-based combination therapies in oncohistone H3K27M-mutant diffuse intrinsic pontine glioma is associated with induction of the integrated stress response, TRAIL death receptor DR5, reduced ClpX and apoptosis.
12/2020	ONC201 and imipridones: Anti-cancer compounds with clinical efficacy.

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Lanlan Zhou Research Topics

Disease

48	Neoplasms (Cancer) 10/2023 - 10/2004
13	Colorectal Neoplasms (Colorectal Cancer) 06/2023 - 01/2015
5	Pancreatic Neoplasms (Pancreatic Cancer) 10/2023 - 01/2021
5	Infections 01/2022 - 09/2020
5	Glioma (Gliomas) 01/2022 - 10/2004
5	Neoplasm Metastasis (Metastasis) 02/2021 - 06/2016
5	Hematologic Neoplasms (Hematological Malignancy) 12/2020 - 11/2016
4	Breast Neoplasms (Breast Cancer) 01/2023 - 01/2016
4	Carcinogenesis 12/2022 - 10/2008
4	Lymphoma (Lymphomas) 01/2022 - 11/2020
3	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 10/2023 - 01/2021
3	Brain Ischemia (Cerebral Ischemia) 04/2023 - 01/2018
3	Endometrial Neoplasms (Endometrial Cancer) 01/2023 - 12/2020
3	Leukemia 01/2022 - 04/2017
3	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2022 - 05/2010
3	Colonic Neoplasms (Colon Cancer) 10/2021 - 09/2012
3	Disease Progression 11/2020 - 01/2015
2	Reperfusion Injury 04/2023 - 01/2018
2	Brain Neoplasms (Brain Tumor) 12/2022 - 01/2021
2	Hyperuricemia 01/2022 - 10/2012
2	Neuroendocrine Tumors (Neuroendocrine Tumor) 01/2022 - 01/2021
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2022 - 01/2018
2	Carcinoma (Carcinomatosis) 10/2021 - 01/2016
2	Stroke (Strokes) 08/2021 - 01/2018
2	Infarction (Infarctions) 08/2021 - 01/2018
2	Ischemic Stroke 08/2021 - 01/2018
2	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 12/2020 - 01/2018
2	Prostatic Neoplasms (Prostate Cancer) 12/2020 - 01/2016
2	COVID-19 11/2020 - 09/2020
2	Lung Neoplasms (Lung Cancer) 11/2020 - 09/2020
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2018 - 01/2015
2	Malignant Mesothelioma 09/2012 - 12/2009
1	Pruritus (Itching) 09/2023
1	Pain (Aches) 09/2023
1	Chronic Pain 09/2023
1	Adenocarcinoma 01/2023
1	Neurofibrosarcoma (MPNST) 01/2023
1	Stomach Neoplasms (Stomach Cancer) 01/2023
1	Osteosarcoma (Osteogenic Sarcoma) 01/2023
1	Ewing Sarcoma (Sarcoma, Ewing) 01/2023

Drug/Important Bio-Agent (IBA)

16	TIC10 compoundIBA 01/2023 - 11/2016
9	CytokinesIBA 02/2023 - 09/2012
6	Proteins (Proteins, Gene)FDA Link 02/2023 - 01/2018
5	Immune Checkpoint InhibitorsIBA 06/2023 - 10/2021
5	Biomarkers (Surrogate Marker)IBA 01/2022 - 06/2016
4	Irinotecan (Camptosar)FDA LinkGeneric 10/2023 - 09/2015
4	Fluorouracil (Carac)FDA LinkGeneric 10/2023 - 01/2015
4	ONC212IBA 01/2023 - 10/2017
4	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 09/2012
3	DNA (Deoxyribonucleic Acid)IBA 12/2022 - 07/2011
3	Interleukin-6 (Interleukin 6)IBA 01/2022 - 09/2020
3	Cisplatin (Platino)FDA LinkGeneric 09/2021 - 07/2011
2	PM 01183IBA 10/2023 - 01/2022
2	Analgesics (Analgesic Drugs)IBA 09/2023 - 09/2012
2	Glycogen Synthase Kinase 3IBA 06/2023 - 02/2023
2	erythromycin propionate-N-acetylcysteinateIBA 04/2023 - 08/2021
2	IntegrinsIBA 01/2023 - 01/2023
2	Death Domain ReceptorsIBA 01/2023 - 01/2021
2	Vorinostat FDA Link 01/2023 - 01/2021
2	ONC206IBA 01/2023 - 10/2017
2	Chimeric Antigen ReceptorsIBA 12/2022 - 01/2022
2	Interleukin-10 (Interleukin 10)IBA 01/2022 - 11/2020
2	Ferritins (Ferritin)IBA 01/2022 - 09/2021
2	1- (4- methylpiperazin- 1- yl)- 3- (5- nitrofuran- 2- yl)prop- 2- en- 1- oneIBA 01/2022 - 09/2015
2	RNA (Ribonucleic Acid)IBA 01/2022 - 09/2012
2	Histones (Histone)IBA 09/2021 - 01/2021
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 09/2021 - 01/2021
2	Platelet Membrane GlycoproteinsIBA 08/2021 - 01/2018
2	Agkistrodon acutus agkisacucetin proteinIBA 08/2021 - 01/2018
2	MicroRNAs (MicroRNA)IBA 02/2021 - 12/2019
2	dipinacoline glutamateIBA 01/2021 - 01/2021
2	Deoxyglucose (2 Deoxy D glucose)IBA 01/2021 - 10/2004
2	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2021 - 11/2020
2	Docetaxel (Taxotere)FDA Link 01/2021 - 07/2011
2	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 10/2004
2	Capecitabine (Xeloda)FDA Link 01/2021 - 01/2015
2	Antiviral Agents (Antivirals)IBA 11/2020 - 09/2020
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 11/2020 - 09/2020
2	Dexamethasone (Maxidex)FDA LinkGeneric 11/2020 - 01/2018
2	Small Interfering RNA (siRNA)IBA 01/2020 - 10/2008
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2018 - 07/2012
2	Sorafenib (BAY 43-9006)FDA Link 07/2011 - 12/2009
1	PlatinumIBA 10/2023
1	Drug CombinationsIBA 10/2023
1	Topoisomerase I InhibitorsIBA 10/2023
1	bovine adrenal medulla 8-22IBA 09/2023
1	vitexinIBA 09/2023
1	Acetic Acid (Vinegar)FDA LinkGeneric 09/2023
1	Formaldehyde (Formol)FDA Link 09/2023
1	Chloroquine (Aralen)FDA LinkGeneric 09/2023
1	Histamine (Histamine Dihydrochloride)FDA Link 09/2023
1	Transient Receptor Potential ChannelsIBA 09/2023
1	Granzymes (Granzyme)IBA 06/2023
1	Histone Deacetylase InhibitorsIBA 01/2023
1	navitoclaxIBA 01/2023
1	PanobinostatIBA 01/2023
1	entinostat (MS 275)IBA 01/2023

Therapy/Procedure

29	Therapeutics 10/2023 - 12/2009
8	Drug Therapy (Chemotherapy) 10/2023 - 07/2011
5	Immunotherapy 01/2023 - 05/2010